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PithaIKambhampatiSSharmaASharmaRMcCreaLMozzerAet al

Journal of Physics D: Applied Physics 48 , 275203, (2015)

Insufficient SAM allows histamine to accumulatecontributing to headaches, restlessness, poor sleep. Neurotransmitter metabolism : SAM supports the conversion and breakdown of dopamine, norepinephrine, and epinephrine via COMT and PNMT